IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

CAISSE DE DEPOT ET PLACEMENT DU QUEBEC's Holding History (CIK: 0000898286)

Note: Option positions (PUT/CALL) are excluded.

Q2 2022

Shares 198,324 Value ($000) $7,342 Avg Close $37.71 Range $31.46 - $44.42

Q4 2020

Shares 7,118 Value ($000) $402 Avg Close $49.83 Range $45.09 - $60.95

Q3 2020

Shares 7,000 Value ($000) $332 Avg Close $55.55 Range $47.19 - $63.49

Q2 2020

Shares 7,400 Value ($000) $436 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 7,166 Value ($000) $339 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 4,000 Value ($000) $242 Avg Close $59.58 Range $53.34 - $66.22

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2022	198,324	$7,342	$37.71	$31.46 - $44.42
Q4 2020	7,118	$402	$49.83	$45.09 - $60.95
Q3 2020	7,000	$332	$55.55	$47.19 - $63.49
Q2 2020	7,400	$436	$55.63	$45.12 - $61.24
Q1 2020	7,166	$339	$55.74	$39.32 - $64.34
Q4 2019	4,000	$242	$59.58	$53.34 - $66.22