IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

DEERFIELD MANAGEMENT COMPANY, L.P.'s Holding History (CIK: 0001009258)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,979,669 Value ($000) $156,612 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 1,979,669 Value ($000) $129,510 Avg Close $48.82 Range $39.72 - $65.55

Q4 2016

Shares 214,095 Value ($000) $10,240 Avg Close $39.57 Range $24.58 - $57.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,979,669	$156,612	$75.30	$64.93 - $83.61
Q3 2025	1,979,669	$129,510	$48.82	$39.72 - $65.55
Q4 2016	214,095	$10,240	$39.57	$24.58 - $57.00