IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

FRANKLIN STREET ADVISORS INC /NC's Holding History (CIK: 0001010873)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016

Shares 13,612 Value ($000) $651 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 13,612 Value ($000) $499 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 13,612 Value ($000) $317 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 15,212 Value ($000) $616 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 18,612 Value ($000) $1,153 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2016	13,612	$651	$39.57	$24.58 - $57.00
Q3 2016	13,612	$499	$31.29	$23.26 - $40.82
Q2 2016	13,612	$317	$32.26	$19.59 - $46.75
Q1 2016	15,212	$616	$40.62	$30.93 - $62.68
Q4 2015	18,612	$1,153	$53.96	$38.30 - $65.34