IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

SOROS FUND MANAGEMENT LLC's Holding History (CIK: 0001029160)

Note: Option positions (PUT/CALL) are excluded.

Q2 2017

Shares 10,700 Value ($000) $544 Avg Close $46.57 Range $37.26 - $55.73

Q4 2016

Shares 4,300 Value ($000) $206 Avg Close $39.57 Range $24.58 - $57.00

Q4 2015

Shares 12,000 Value ($000) $743 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2017	10,700	$544	$46.57	$37.26 - $55.73
Q4 2016	4,300	$206	$39.57	$24.58 - $57.00
Q4 2015	12,000	$743	$53.96	$38.30 - $65.34