IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

PARADIGM ASSET MANAGEMENT CO LLC's Holding History (CIK: 0001034549)

Note: Option positions (PUT/CALL) are excluded.

Q2 2017

Shares 1,100 Value ($000) $55,957 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 2,200 Value ($000) $88,440 Avg Close $44.91 Range $37.29 - $56.91

Q4 2016

Shares 9,300 Value ($000) $444,819 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 9,600 Value ($000) $351,744 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 11,600 Value ($000) $270,164 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 12,200 Value ($000) $494,100 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 12,200 Value ($000) $755,546 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2017	1,100	$55,957	$46.57	$37.26 - $55.73
Q1 2017	2,200	$88,440	$44.91	$37.29 - $56.91
Q4 2016	9,300	$444,819	$39.57	$24.58 - $57.00
Q3 2016	9,600	$351,744	$31.29	$23.26 - $40.82
Q2 2016	11,600	$270,164	$32.26	$19.59 - $46.75
Q1 2016	12,200	$494,100	$40.62	$30.93 - $62.68
Q4 2015	12,200	$755,546	$53.96	$38.30 - $65.34