IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Artal Group S.A.'s Holding History (CIK: 0001053906)

Note: Option positions (PUT/CALL) are excluded.

Q2 2017

Shares 135,000 Value ($000) $6,867 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 250,000 Value ($000) $10,050 Avg Close $44.91 Range $37.29 - $56.91

Q1 2016

Shares 350,000 Value ($000) $14,175 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 350,000 Value ($000) $21,676 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2017	135,000	$6,867	$46.57	$37.26 - $55.73
Q1 2017	250,000	$10,050	$44.91	$37.29 - $56.91
Q1 2016	350,000	$14,175	$40.62	$30.93 - $62.68
Q4 2015	350,000	$21,676	$53.96	$38.30 - $65.34