IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Asset Management One Co., Ltd.'s Holding History (CIK: 0001068855)

Note: Option positions (PUT/CALL) are excluded.

Q1 2021

Shares 60,617 Value ($000) $2,725 Avg Close $55.77 Range $41.42 - $64.37

Q4 2020

Shares 64,141 Value ($000) $3,656 Avg Close $49.83 Range $45.09 - $60.95

Q3 2020

Shares 64,141 Value ($000) $3,042 Avg Close $55.55 Range $47.19 - $63.49

Q2 2020

Shares 64,161 Value ($000) $3,784 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 64,607 Value ($000) $3,054 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 65,883 Value ($000) $3,980 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 65,368 Value ($000) $3,917 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 62,644 Value ($000) $4,028 Avg Close $70.69 Range $61.91 - $86.58

Q2 2016

Shares 10,990 Value ($000) $254 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 10,990 Value ($000) $428 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 10,990 Value ($000) $670 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2021	60,617	$2,725	$55.77	$41.42 - $64.37
Q4 2020	64,141	$3,656	$49.83	$45.09 - $60.95
Q3 2020	64,141	$3,042	$55.55	$47.19 - $63.49
Q2 2020	64,161	$3,784	$55.63	$45.12 - $61.24
Q1 2020	64,607	$3,054	$55.74	$39.32 - $64.34
Q4 2019	65,883	$3,980	$59.58	$53.34 - $66.22
Q3 2019	65,368	$3,917	$65.17	$58.48 - $73.09
Q2 2019	62,644	$4,028	$70.69	$61.91 - $86.58
Q2 2016	10,990	$254	$32.26	$19.59 - $46.75
Q1 2016	10,990	$428	$40.62	$30.93 - $62.68
Q4 2015	10,990	$670	$53.96	$38.30 - $65.34