IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

GREAT LAKES ADVISORS, LLC's Holding History (CIK: 0001078013)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 149,180 Value ($000) $11,802 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 186,950 Value ($000) $12,230 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 399,646 Value ($000) $15,790 Avg Close $32.73 Range $23.95 - $40.61

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	149,180	$11,802	$75.30	$64.93 - $83.61
Q3 2025	186,950	$12,230	$48.82	$39.72 - $65.55
Q2 2025	399,646	$15,790	$32.73	$23.95 - $40.61