IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

D.A. DAVIDSON & CO.'s Holding History (CIK: 0001080107)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019

Shares 48,172 Value ($000) $3,910 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 49,707 Value ($000) $2,687 Avg Close $51.00 Range $43.27 - $59.81

Q3 2018

Shares 50,411 Value ($000) $2,600 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 50,336 Value ($000) $2,098 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 50,785 Value ($000) $2,239 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 50,559 Value ($000) $2,543 Avg Close $54.84 Range $50.02 - $65.51

Q3 2017

Shares 50,929 Value ($000) $2,582 Avg Close $52.38 Range $43.75 - $60.01

Q2 2017

Shares 50,957 Value ($000) $2,592 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 51,012 Value ($000) $2,050 Avg Close $44.91 Range $37.29 - $56.91

Q4 2016

Shares 52,373 Value ($000) $2,503 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 31,514 Value ($000) $1,152 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 31,556 Value ($000) $733 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 34,352 Value ($000) $1,389 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 16,480 Value ($000) $1,018 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2019	48,172	$3,910	$64.51	$52.45 - $81.59
Q4 2018	49,707	$2,687	$51.00	$43.27 - $59.81
Q3 2018	50,411	$2,600	$46.98	$41.05 - $54.85
Q2 2018	50,336	$2,098	$44.30	$39.07 - $51.00
Q1 2018	50,785	$2,239	$50.80	$43.38 - $56.47
Q4 2017	50,559	$2,543	$54.84	$50.02 - $65.51
Q3 2017	50,929	$2,582	$52.38	$43.75 - $60.01
Q2 2017	50,957	$2,592	$46.57	$37.26 - $55.73
Q1 2017	51,012	$2,050	$44.91	$37.29 - $56.91
Q4 2016	52,373	$2,503	$39.57	$24.58 - $57.00
Q3 2016	31,514	$1,152	$31.29	$23.26 - $40.82
Q2 2016	31,556	$733	$32.26	$19.59 - $46.75
Q1 2016	34,352	$1,389	$40.62	$30.93 - $62.68
Q4 2015	16,480	$1,018	$53.96	$38.30 - $65.34