IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

GW&K Investment Management, LLC's Holding History (CIK: 0001082917)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 786,668 Value ($000) $62 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 264,007 Value ($000) $17 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 448,830 Value ($000) $18 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 182,309 Value ($000) $6 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 187,220 Value ($000) $7 Avg Close $37.38 Range $33.33 - $40.58

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	786,668	$62	$75.30	$64.93 - $83.61
Q3 2025	264,007	$17	$48.82	$39.72 - $65.55
Q2 2025	448,830	$18	$32.73	$23.95 - $40.61
Q1 2025	182,309	$6	$32.75	$29.61 - $35.48
Q4 2024	187,220	$7	$37.38	$33.33 - $40.58