IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

MARINO, STRAM & ASSOCIATES LLC's Holding History (CIK: 0001099762)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019

Shares 500 Value ($000) $41 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 500 Value ($000) $27 Avg Close $51.00 Range $43.27 - $59.81

Q3 2018

Shares 500 Value ($000) $26 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 500 Value ($000) $21 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 500 Value ($000) $22 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 500 Value ($000) $25 Avg Close $54.84 Range $50.02 - $65.51

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2019	500	$41	$64.51	$52.45 - $81.59
Q4 2018	500	$27	$51.00	$43.27 - $59.81
Q3 2018	500	$26	$46.98	$41.05 - $54.85
Q2 2018	500	$21	$44.30	$39.07 - $51.00
Q1 2018	500	$22	$50.80	$43.38 - $56.47
Q4 2017	500	$25	$54.84	$50.02 - $65.51