IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

CAPITAL COUNSEL LLC/NY's Holding History (CIK: 0001114928)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 49,605 Value ($000) $3,924 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 49,605 Value ($000) $3,245 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 50,205 Value ($000) $1,984 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 37,080 Value ($000) $1,119 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 37,080 Value ($000) $1,296 Avg Close $37.38 Range $33.33 - $40.58

Q3 2024

Shares 37,080 Value ($000) $1,485 Avg Close $46.53 Range $39.48 - $52.34

Q2 2024

Shares 37,080 Value ($000) $1,767 Avg Close $41.01 Range $35.95 - $47.86

Q1 2024

Shares 39,580 Value ($000) $1,716 Avg Close $47.67 Range $41.60 - $54.44

Q4 2023

Shares 40,080 Value ($000) $2,028 Avg Close $47.90 Range $41.84 - $52.27

Q3 2023

Shares 40,230 Value ($000) $1,825 Avg Close $41.26 Range $38.26 - $47.72

Q2 2023

Shares 40,230 Value ($000) $1,651 Avg Close $38.43 Range $34.32 - $43.55

Q1 2023

Shares 40,230 Value ($000) $1,438 Avg Close $37.55 Range $32.69 - $41.73

Q4 2022

Shares 40,230 Value ($000) $1,519 Avg Close $42.06 Range $36.69 - $47.74

Q3 2022

Shares 40,230 Value ($000) $1,779 Avg Close $42.14 Range $35.95 - $48.82

Q2 2022

Shares 41,010 Value ($000) $1,518 Avg Close $37.71 Range $31.46 - $44.42

Q1 2022

Shares 41,010 Value ($000) $1,519 Avg Close $32.73 Range $28.25 - $37.15

Q4 2021

Shares 40,580 Value ($000) $1,235 Avg Close $31.48 Range $25.04 - $35.80

Q3 2021

Shares 40,580 Value ($000) $1,361 Avg Close $37.68 Range $33.52 - $40.99

Q2 2021

Shares 40,580 Value ($000) $1,619 Avg Close $39.17 Range $34.43 - $47.87

Q1 2021

Shares 42,080 Value ($000) $1,892 Avg Close $55.77 Range $41.42 - $64.37

Q4 2020

Shares 42,080 Value ($000) $2,379 Avg Close $49.83 Range $45.09 - $60.95

Q3 2020

Shares 42,080 Value ($000) $1,997 Avg Close $55.55 Range $47.19 - $63.49

Q2 2020

Shares 39,380 Value ($000) $2,322 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 39,380 Value ($000) $1,862 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 39,380 Value ($000) $2,379 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 39,380 Value ($000) $2,359 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 39,380 Value ($000) $2,531 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 44,380 Value ($000) $3,602 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 43,380 Value ($000) $2,345 Avg Close $51.00 Range $43.27 - $59.81

Q3 2018

Shares 43,380 Value ($000) $2,238 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 43,380 Value ($000) $1,808 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 42,380 Value ($000) $1,868 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 41,280 Value ($000) $2,076 Avg Close $54.84 Range $50.02 - $65.51

Q3 2017

Shares 41,280 Value ($000) $2,093 Avg Close $52.38 Range $43.75 - $60.01

Q2 2017

Shares 41,280 Value ($000) $2,100 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 38,030 Value ($000) $1,529 Avg Close $44.91 Range $37.29 - $56.91

Q4 2016

Shares 37,530 Value ($000) $1,795 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 37,530 Value ($000) $1,375 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 28,530 Value ($000) $664 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 18,430 Value ($000) $746 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 18,000 Value ($000) $1,115 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	49,605	$3,924	$75.30	$64.93 - $83.61
Q3 2025	49,605	$3,245	$48.82	$39.72 - $65.55
Q2 2025	50,205	$1,984	$32.73	$23.95 - $40.61
Q1 2025	37,080	$1,119	$32.75	$29.61 - $35.48
Q4 2024	37,080	$1,296	$37.38	$33.33 - $40.58
Q3 2024	37,080	$1,485	$46.53	$39.48 - $52.34
Q2 2024	37,080	$1,767	$41.01	$35.95 - $47.86
Q1 2024	39,580	$1,716	$47.67	$41.60 - $54.44
Q4 2023	40,080	$2,028	$47.90	$41.84 - $52.27
Q3 2023	40,230	$1,825	$41.26	$38.26 - $47.72
Q2 2023	40,230	$1,651	$38.43	$34.32 - $43.55
Q1 2023	40,230	$1,438	$37.55	$32.69 - $41.73
Q4 2022	40,230	$1,519	$42.06	$36.69 - $47.74
Q3 2022	40,230	$1,779	$42.14	$35.95 - $48.82
Q2 2022	41,010	$1,518	$37.71	$31.46 - $44.42
Q1 2022	41,010	$1,519	$32.73	$28.25 - $37.15
Q4 2021	40,580	$1,235	$31.48	$25.04 - $35.80
Q3 2021	40,580	$1,361	$37.68	$33.52 - $40.99
Q2 2021	40,580	$1,619	$39.17	$34.43 - $47.87
Q1 2021	42,080	$1,892	$55.77	$41.42 - $64.37
Q4 2020	42,080	$2,379	$49.83	$45.09 - $60.95
Q3 2020	42,080	$1,997	$55.55	$47.19 - $63.49
Q2 2020	39,380	$2,322	$55.63	$45.12 - $61.24
Q1 2020	39,380	$1,862	$55.74	$39.32 - $64.34
Q4 2019	39,380	$2,379	$59.58	$53.34 - $66.22
Q3 2019	39,380	$2,359	$65.17	$58.48 - $73.09
Q2 2019	39,380	$2,531	$70.69	$61.91 - $86.58
Q1 2019	44,380	$3,602	$64.51	$52.45 - $81.59
Q4 2018	43,380	$2,345	$51.00	$43.27 - $59.81
Q3 2018	43,380	$2,238	$46.98	$41.05 - $54.85
Q2 2018	43,380	$1,808	$44.30	$39.07 - $51.00
Q1 2018	42,380	$1,868	$50.80	$43.38 - $56.47
Q4 2017	41,280	$2,076	$54.84	$50.02 - $65.51
Q3 2017	41,280	$2,093	$52.38	$43.75 - $60.01
Q2 2017	41,280	$2,100	$46.57	$37.26 - $55.73
Q1 2017	38,030	$1,529	$44.91	$37.29 - $56.91
Q4 2016	37,530	$1,795	$39.57	$24.58 - $57.00
Q3 2016	37,530	$1,375	$31.29	$23.26 - $40.82
Q2 2016	28,530	$664	$32.26	$19.59 - $46.75
Q1 2016	18,430	$746	$40.62	$30.93 - $62.68
Q4 2015	18,000	$1,115	$53.96	$38.30 - $65.34