IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

FIRST INTERSTATE BANK's Holding History (CIK: 0001125727)

Note: Option positions (PUT/CALL) are excluded.

Q4 2019

Shares 419 Value ($000) $25 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 419 Value ($000) $25 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 419 Value ($000) $27 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 419 Value ($000) $34 Avg Close $64.51 Range $52.45 - $81.59

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2019	419	$25	$59.58	$53.34 - $66.22
Q3 2019	419	$25	$65.17	$58.48 - $73.09
Q2 2019	419	$27	$70.69	$61.91 - $86.58
Q1 2019	419	$34	$64.51	$52.45 - $81.59