IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp's Holding History (CIK: 0001228242)

Note: Option positions (PUT/CALL) are excluded.

Q1 2021

Shares 21,768 Value ($000) $979 Avg Close $55.77 Range $41.42 - $64.37

Q4 2020

Shares 22,419 Value ($000) $1,268 Avg Close $49.83 Range $45.09 - $60.95

Q3 2020

Shares 22,954 Value ($000) $1,089 Avg Close $55.55 Range $47.19 - $63.49

Q2 2020

Shares 21,413 Value ($000) $1,263 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 14,618 Value ($000) $691 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 31,452 Value ($000) $1,900 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 18,240 Value ($000) $1,093 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 25,452 Value ($000) $1,636 Avg Close $70.69 Range $61.91 - $86.58

Q2 2016

Shares 23,515 Value ($000) $548 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 48,627 Value ($000) $1,969 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 105,881 Value ($000) $6,557 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2021	21,768	$979	$55.77	$41.42 - $64.37
Q4 2020	22,419	$1,268	$49.83	$45.09 - $60.95
Q3 2020	22,954	$1,089	$55.55	$47.19 - $63.49
Q2 2020	21,413	$1,263	$55.63	$45.12 - $61.24
Q1 2020	14,618	$691	$55.74	$39.32 - $64.34
Q4 2019	31,452	$1,900	$59.58	$53.34 - $66.22
Q3 2019	18,240	$1,093	$65.17	$58.48 - $73.09
Q2 2019	25,452	$1,636	$70.69	$61.91 - $86.58
Q2 2016	23,515	$548	$32.26	$19.59 - $46.75
Q1 2016	48,627	$1,969	$40.62	$30.93 - $62.68
Q4 2015	105,881	$6,557	$53.96	$38.30 - $65.34