IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

CANADA PENSION PLAN INVESTMENT BOARD's Holding History (CIK: 0001283718)

Note: Option positions (PUT/CALL) are excluded.

Q4 2024

Shares 19,900 Value ($000) $696 Avg Close $37.38 Range $33.33 - $40.58

Q3 2024

Shares 11,200 Value ($000) $449 Avg Close $46.53 Range $39.48 - $52.34

Q2 2023

Shares 21,019 Value ($000) $862 Avg Close $38.43 Range $34.32 - $43.55

Q1 2023

Shares 78,619 Value ($000) $2,810 Avg Close $37.55 Range $32.69 - $41.73

Q4 2022

Shares 72,900 Value ($000) $2,753 Avg Close $42.06 Range $36.69 - $47.74

Q2 2022

Shares 3,124 Value ($000) $116 Avg Close $37.71 Range $31.46 - $44.42

Q1 2022

Shares 9,611 Value ($000) $356 Avg Close $32.73 Range $28.25 - $37.15

Q4 2021

Shares 57,924 Value ($000) $1,763 Avg Close $31.48 Range $25.04 - $35.80

Q1 2021

Shares 36,762 Value ($000) $1,653 Avg Close $55.77 Range $41.42 - $64.37

Q4 2020

Shares 42,687 Value ($000) $2,414 Avg Close $49.83 Range $45.09 - $60.95

Q3 2020

Shares 20,625 Value ($000) $979 Avg Close $55.55 Range $47.19 - $63.49

Q2 2020

Shares 140,226 Value ($000) $8,268 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 92,951 Value ($000) $4,395 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 59,680 Value ($000) $3,605 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 142,921 Value ($000) $8,562 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 397,664 Value ($000) $25,558 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 388,255 Value ($000) $31,515 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 412,500 Value ($000) $22,298 Avg Close $51.00 Range $43.27 - $59.81

Q3 2018

Shares 391,800 Value ($000) $20,209 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 321,700 Value ($000) $13,405 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 269,300 Value ($000) $11,871 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 145,100 Value ($000) $7,299 Avg Close $54.84 Range $50.02 - $65.51

Q3 2017

Shares 118,700 Value ($000) $6,018 Avg Close $52.38 Range $43.75 - $60.01

Q2 2017

Shares 148,000 Value ($000) $7,529 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 111,410 Value ($000) $4,479 Avg Close $44.91 Range $37.29 - $56.91

Q4 2016

Shares 64,610 Value ($000) $3,090 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 51,310 Value ($000) $1,880 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 37,510 Value ($000) $874 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 13,400 Value ($000) $543 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 8,396 Value ($000) $520 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2024	19,900	$696	$37.38	$33.33 - $40.58
Q3 2024	11,200	$449	$46.53	$39.48 - $52.34
Q2 2023	21,019	$862	$38.43	$34.32 - $43.55
Q1 2023	78,619	$2,810	$37.55	$32.69 - $41.73
Q4 2022	72,900	$2,753	$42.06	$36.69 - $47.74
Q2 2022	3,124	$116	$37.71	$31.46 - $44.42
Q1 2022	9,611	$356	$32.73	$28.25 - $37.15
Q4 2021	57,924	$1,763	$31.48	$25.04 - $35.80
Q1 2021	36,762	$1,653	$55.77	$41.42 - $64.37
Q4 2020	42,687	$2,414	$49.83	$45.09 - $60.95
Q3 2020	20,625	$979	$55.55	$47.19 - $63.49
Q2 2020	140,226	$8,268	$55.63	$45.12 - $61.24
Q1 2020	92,951	$4,395	$55.74	$39.32 - $64.34
Q4 2019	59,680	$3,605	$59.58	$53.34 - $66.22
Q3 2019	142,921	$8,562	$65.17	$58.48 - $73.09
Q2 2019	397,664	$25,558	$70.69	$61.91 - $86.58
Q1 2019	388,255	$31,515	$64.51	$52.45 - $81.59
Q4 2018	412,500	$22,298	$51.00	$43.27 - $59.81
Q3 2018	391,800	$20,209	$46.98	$41.05 - $54.85
Q2 2018	321,700	$13,405	$44.30	$39.07 - $51.00
Q1 2018	269,300	$11,871	$50.80	$43.38 - $56.47
Q4 2017	145,100	$7,299	$54.84	$50.02 - $65.51
Q3 2017	118,700	$6,018	$52.38	$43.75 - $60.01
Q2 2017	148,000	$7,529	$46.57	$37.26 - $55.73
Q1 2017	111,410	$4,479	$44.91	$37.29 - $56.91
Q4 2016	64,610	$3,090	$39.57	$24.58 - $57.00
Q3 2016	51,310	$1,880	$31.29	$23.26 - $40.82
Q2 2016	37,510	$874	$32.26	$19.59 - $46.75
Q1 2016	13,400	$543	$40.62	$30.93 - $62.68
Q4 2015	8,396	$520	$53.96	$38.30 - $65.34