IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Broderick Brian C's Holding History (CIK: 0001314376)

Note: Option positions (PUT/CALL) are excluded.

Q1 2017

Shares 18,666 Value ($000) $750 Avg Close $44.91 Range $37.29 - $56.91

Q4 2016

Shares 22,241 Value ($000) $1,064 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 22,641 Value ($000) $829 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 24,444 Value ($000) $570 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 19,495 Value ($000) $788 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 19,160 Value ($000) $1,186 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2017	18,666	$750	$44.91	$37.29 - $56.91
Q4 2016	22,241	$1,064	$39.57	$24.58 - $57.00
Q3 2016	22,641	$829	$31.29	$23.26 - $40.82
Q2 2016	24,444	$570	$32.26	$19.59 - $46.75
Q1 2016	19,495	$788	$40.62	$30.93 - $62.68
Q4 2015	19,160	$1,186	$53.96	$38.30 - $65.34