IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Kidder Stephen W's Holding History (CIK: 0001314377)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016

Shares 8,780 Value ($000) $421 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 7,455 Value ($000) $273 Avg Close $31.29 Range $23.26 - $40.82

Q1 2016

Shares 6,995 Value ($000) $283 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 6,230 Value ($000) $386 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2016	8,780	$421	$39.57	$24.58 - $57.00
Q3 2016	7,455	$273	$31.29	$23.26 - $40.82
Q1 2016	6,995	$283	$40.62	$30.93 - $62.68
Q4 2015	6,230	$386	$53.96	$38.30 - $65.34