IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Altshuler Shaham Ltd's Holding History (CIK: 0001324290)

Note: Option positions (PUT/CALL) are excluded.

Q4 2022

Shares 695 Value ($000) $26 Avg Close $42.06 Range $36.69 - $47.74

Q3 2022

Shares 1,385 Value ($000) $61 Avg Close $42.14 Range $35.95 - $48.82

Q2 2022

Shares 834 Value ($000) $31 Avg Close $37.71 Range $31.46 - $44.42

Q2 2019

Shares 155 Value ($000) $10 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 113 Value ($000) $9 Avg Close $64.51 Range $52.45 - $81.59

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2022	695	$26	$42.06	$36.69 - $47.74
Q3 2022	1,385	$61	$42.14	$35.95 - $48.82
Q2 2022	834	$31	$37.71	$31.46 - $44.42
Q2 2019	155	$10	$70.69	$61.91 - $86.58
Q1 2019	113	$9	$64.51	$52.45 - $81.59