IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Plante Moran Financial Advisors, LLC's Holding History (CIK: 0001424717)

Note: Option positions (PUT/CALL) are excluded.

Q2 2023

Shares 40 Value ($000) $2 Avg Close $38.43 Range $34.32 - $43.55

Q2 2020

Shares 11 Value ($000) $1 Avg Close $55.63 Range $45.12 - $61.24

Q2 2016

Shares 47 Value ($000) $1 Avg Close $32.26 Range $19.59 - $46.75

Q4 2015

Shares 269 Value ($000) $17 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2023	40	$2	$38.43	$34.32 - $43.55
Q2 2020	11	$1	$55.63	$45.12 - $61.24
Q2 2016	47	$1	$32.26	$19.59 - $46.75
Q4 2015	269	$17	$53.96	$38.30 - $65.34