IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Apriem Advisors's Holding History (CIK: 0001425165)

Note: Option positions (PUT/CALL) are excluded.

Q3 2016
Shares 1,000 Value ($000) $37 Avg Close $31.29 Range $23.26 - $40.82
Q2 2016
Shares 1,000 Value ($000) $23 Avg Close $32.26 Range $19.59 - $46.75
Q1 2016
Shares 1,000 Value ($000) $41 Avg Close $40.62 Range $30.93 - $62.68