IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Harel Insurance Investments & Financial Services Ltd.'s Holding History (CIK: 0001429390)

Note: Option positions (PUT/CALL) are excluded.

Q2 2020

Shares 892 Value ($000) $53 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 892 Value ($000) $42 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 1,078 Value ($000) $65 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 165 Value ($000) $10 Avg Close $65.17 Range $58.48 - $73.09

Q4 2017

Shares 530 Value ($000) $27 Avg Close $54.84 Range $50.02 - $65.51

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2020	892	$53	$55.63	$45.12 - $61.24
Q1 2020	892	$42	$55.74	$39.32 - $64.34
Q4 2019	1,078	$65	$59.58	$53.34 - $66.22
Q3 2019	165	$10	$65.17	$58.48 - $73.09
Q4 2017	530	$27	$54.84	$50.02 - $65.51