IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

APG Asset Management N.V.'s Holding History (CIK: 0001434819)

Note: Option positions (PUT/CALL) are excluded.

Q2 2021

Shares 28,200 Value ($000) $949 Avg Close $39.17 Range $34.43 - $47.87

Q1 2020

Shares 183,160 Value ($000) $8,660 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 228,001 Value ($000) $12,270 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 669,687 Value ($000) $36,801 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 193,600 Value ($000) $10,926 Avg Close $70.69 Range $61.91 - $86.58

Q2 2017

Shares 62,464 Value ($000) $3,178 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 62,464 Value ($000) $2,511 Avg Close $44.91 Range $37.29 - $56.91

Q4 2016

Shares 62,464 Value ($000) $2,833 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 74,864 Value ($000) $2,743 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 143,564 Value ($000) $3,344 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 74,864 Value ($000) $3,032 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 39,811 Value ($000) $2,465,495 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2021	28,200	$949	$39.17	$34.43 - $47.87
Q1 2020	183,160	$8,660	$55.74	$39.32 - $64.34
Q4 2019	228,001	$12,270	$59.58	$53.34 - $66.22
Q3 2019	669,687	$36,801	$65.17	$58.48 - $73.09
Q2 2019	193,600	$10,926	$70.69	$61.91 - $86.58
Q2 2017	62,464	$3,178	$46.57	$37.26 - $55.73
Q1 2017	62,464	$2,511	$44.91	$37.29 - $56.91
Q4 2016	62,464	$2,833	$39.57	$24.58 - $57.00
Q3 2016	74,864	$2,743	$31.29	$23.26 - $40.82
Q2 2016	143,564	$3,344	$32.26	$19.59 - $46.75
Q1 2016	74,864	$3,032	$40.62	$30.93 - $62.68
Q4 2015	39,811	$2,465,495	$53.96	$38.30 - $65.34