IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

GAM Holding AG's Holding History (CIK: 0001438848)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016

Shares 7,727 Value ($000) $180 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 3,536 Value ($000) $143 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 3,536 Value ($000) $219 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2016	7,727	$180	$32.26	$19.59 - $46.75
Q1 2016	3,536	$143	$40.62	$30.93 - $62.68
Q4 2015	3,536	$219	$53.96	$38.30 - $65.34