IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

PFM Health Sciences, LP's Holding History (CIK: 0001442756)

Note: Option positions (PUT/CALL) are excluded.

Q4 2020

Shares 263,412 Value ($000) $14,893 Avg Close $49.83 Range $45.09 - $60.95

Q4 2016

Shares 470,534 Value ($000) $22,506 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 649,716 Value ($000) $23,806 Avg Close $31.29 Range $23.26 - $40.82

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2020	263,412	$14,893	$49.83	$45.09 - $60.95
Q4 2016	470,534	$22,506	$39.57	$24.58 - $57.00
Q3 2016	649,716	$23,806	$31.29	$23.26 - $40.82