IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Quantitative Investment Management, LLC's Holding History (CIK: 0001445911)

Note: Option positions (PUT/CALL) are excluded.

Q1 2021

Shares 9,931 Value ($000) $446 Avg Close $55.77 Range $41.42 - $64.37

Q4 2020

Shares 18,685 Value ($000) $1,056 Avg Close $49.83 Range $45.09 - $60.95

Q4 2019

Shares 46,546 Value ($000) $2,811 Avg Close $59.58 Range $53.34 - $66.22

Q2 2019

Shares 138,126 Value ($000) $8,877 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 57,639 Value ($000) $4,678 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 5,900 Value ($000) $318 Avg Close $51.00 Range $43.27 - $59.81

Q3 2018

Shares 18,200 Value ($000) $938 Avg Close $46.98 Range $41.05 - $54.85

Q2 2017

Shares 91,000 Value ($000) $4,629 Avg Close $46.57 Range $37.26 - $55.73

Q2 2016

Shares 51,400 Value ($000) $1,197 Avg Close $32.26 Range $19.59 - $46.75

Q4 2015

Shares 30,900 Value ($000) $1,913 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2021	9,931	$446	$55.77	$41.42 - $64.37
Q4 2020	18,685	$1,056	$49.83	$45.09 - $60.95
Q4 2019	46,546	$2,811	$59.58	$53.34 - $66.22
Q2 2019	138,126	$8,877	$70.69	$61.91 - $86.58
Q1 2019	57,639	$4,678	$64.51	$52.45 - $81.59
Q4 2018	5,900	$318	$51.00	$43.27 - $59.81
Q3 2018	18,200	$938	$46.98	$41.05 - $54.85
Q2 2017	91,000	$4,629	$46.57	$37.26 - $55.73
Q2 2016	51,400	$1,197	$32.26	$19.59 - $46.75
Q4 2015	30,900	$1,913	$53.96	$38.30 - $65.34