IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Alyeska Investment Group, L.P.'s Holding History (CIK: 0001453072)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 481,711 Value ($000) $38,108 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 311,258 Value ($000) $20,362 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 159,008 Value ($000) $6,282 Avg Close $32.73 Range $23.95 - $40.61

Q4 2024

Shares 150,000 Value ($000) $5,244 Avg Close $37.38 Range $33.33 - $40.58

Q3 2024

Shares 168,951 Value ($000) $6,768 Avg Close $46.53 Range $39.48 - $52.34

Q1 2021

Shares 427,990 Value ($000) $19,242 Avg Close $55.77 Range $41.42 - $64.37

Q4 2020

Shares 202,477 Value ($000) $11,448 Avg Close $49.83 Range $45.09 - $60.95

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	481,711	$38,108	$75.30	$64.93 - $83.61
Q3 2025	311,258	$20,362	$48.82	$39.72 - $65.55
Q2 2025	159,008	$6,282	$32.73	$23.95 - $40.61
Q4 2024	150,000	$5,244	$37.38	$33.33 - $40.58
Q3 2024	168,951	$6,768	$46.53	$39.48 - $52.34
Q1 2021	427,990	$19,242	$55.77	$41.42 - $64.37
Q4 2020	202,477	$11,448	$49.83	$45.09 - $60.95