IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Mitsubishi UFJ Trust & Banking Corp's Holding History (CIK: 0001462160)

Note: Option positions (PUT/CALL) are excluded.

Q3 2021

Shares 50 Value ($000) $2 Avg Close $37.68 Range $33.52 - $40.99

Q2 2021

Shares 50 Value ($000) $2 Avg Close $39.17 Range $34.43 - $47.87

Q1 2021

Shares 79,951 Value ($000) $3,605 Avg Close $55.77 Range $41.42 - $64.37

Q4 2020

Shares 96,409 Value ($000) $5,451 Avg Close $49.83 Range $45.09 - $60.95

Q3 2020

Shares 391,106 Value ($000) $18,558 Avg Close $55.55 Range $47.19 - $63.49

Q2 2020

Shares 464,875 Value ($000) $27,409 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 467,730 Value ($000) $22,114 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 473,276 Value ($000) $28,591 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 475,511 Value ($000) $28,488 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 505,088 Value ($000) $32,462 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 370,170 Value ($000) $30,047 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 372,010 Value ($000) $20,111 Avg Close $51.00 Range $43.27 - $59.81

Q3 2018

Shares 379,410 Value ($000) $19,570 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 372,620 Value ($000) $15,527 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 256,810 Value ($000) $11,320 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 359,750 Value ($000) $18,095 Avg Close $54.84 Range $50.02 - $65.51

Q3 2017

Shares 368,980 Value ($000) $18,707 Avg Close $52.38 Range $43.75 - $60.01

Q2 2017

Shares 369,590 Value ($000) $18,801 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 377,590 Value ($000) $15,179 Avg Close $44.91 Range $37.29 - $56.91

Q4 2016

Shares 391,690 Value ($000) $18,735 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 387,820 Value ($000) $14,210 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 646,159 Value ($000) $15,049 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 558,782 Value ($000) $22,631 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 551,843 Value ($000) $34,176 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2021	50	$2	$37.68	$33.52 - $40.99
Q2 2021	50	$2	$39.17	$34.43 - $47.87
Q1 2021	79,951	$3,605	$55.77	$41.42 - $64.37
Q4 2020	96,409	$5,451	$49.83	$45.09 - $60.95
Q3 2020	391,106	$18,558	$55.55	$47.19 - $63.49
Q2 2020	464,875	$27,409	$55.63	$45.12 - $61.24
Q1 2020	467,730	$22,114	$55.74	$39.32 - $64.34
Q4 2019	473,276	$28,591	$59.58	$53.34 - $66.22
Q3 2019	475,511	$28,488	$65.17	$58.48 - $73.09
Q2 2019	505,088	$32,462	$70.69	$61.91 - $86.58
Q1 2019	370,170	$30,047	$64.51	$52.45 - $81.59
Q4 2018	372,010	$20,111	$51.00	$43.27 - $59.81
Q3 2018	379,410	$19,570	$46.98	$41.05 - $54.85
Q2 2018	372,620	$15,527	$44.30	$39.07 - $51.00
Q1 2018	256,810	$11,320	$50.80	$43.38 - $56.47
Q4 2017	359,750	$18,095	$54.84	$50.02 - $65.51
Q3 2017	368,980	$18,707	$52.38	$43.75 - $60.01
Q2 2017	369,590	$18,801	$46.57	$37.26 - $55.73
Q1 2017	377,590	$15,179	$44.91	$37.29 - $56.91
Q4 2016	391,690	$18,735	$39.57	$24.58 - $57.00
Q3 2016	387,820	$14,210	$31.29	$23.26 - $40.82
Q2 2016	646,159	$15,049	$32.26	$19.59 - $46.75
Q1 2016	558,782	$22,631	$40.62	$30.93 - $62.68
Q4 2015	551,843	$34,176	$53.96	$38.30 - $65.34