IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

HARBOR INVESTMENT ADVISORY, LLC's Holding History (CIK: 0001468792)

Note: Option positions (PUT/CALL) are excluded.

Q2 2021

Shares 38 Value ($000) $2 Avg Close $39.17 Range $34.43 - $47.87

Q1 2021

Shares 38 Value ($000) $2 Avg Close $55.77 Range $41.42 - $64.37

Q4 2020

Shares 38 Value ($000) $2 Avg Close $49.83 Range $45.09 - $60.95

Q3 2020

Shares 38 Value ($000) $2 Avg Close $55.55 Range $47.19 - $63.49

Q2 2020

Shares 38 Value ($000) $2 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 38 Value ($000) $2 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 38 Value ($000) $2 Avg Close $59.58 Range $53.34 - $66.22

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2021	38	$2	$39.17	$34.43 - $47.87
Q1 2021	38	$2	$55.77	$41.42 - $64.37
Q4 2020	38	$2	$49.83	$45.09 - $60.95
Q3 2020	38	$2	$55.55	$47.19 - $63.49
Q2 2020	38	$2	$55.63	$45.12 - $61.24
Q1 2020	38	$2	$55.74	$39.32 - $64.34
Q4 2019	38	$2	$59.58	$53.34 - $66.22