IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Asset Dedication, LLC's Holding History (CIK: 0001475896)

Note: Option positions (PUT/CALL) are excluded.

Q2 2025

Shares 59 Value ($000) $2 Avg Close $32.73 Range $23.95 - $40.61

Q3 2016

Shares 100 Value ($000) $4 Avg Close $31.29 Range $23.26 - $40.82

Q4 2015

Shares 100 Value ($000) $6 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2025	59	$2	$32.73	$23.95 - $40.61
Q3 2016	100	$4	$31.29	$23.26 - $40.82
Q4 2015	100	$6	$53.96	$38.30 - $65.34