IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 3,052,111 Value ($000) $241,453 Avg Close $75.30 Range $64.93 - $83.61
Q3 2025
Shares 2,073,111 Value ($000) $135,623 Avg Close $48.82 Range $39.72 - $65.55
Q2 2025
Shares 2,667,611 Value ($000) $105,397 Avg Close $32.73 Range $23.95 - $40.61
Q1 2025
Shares 2,092,011 Value ($000) $63,116 Avg Close $32.75 Range $29.61 - $35.48
Q4 2024
Shares 1,349,211 Value ($000) $47,168 Avg Close $37.38 Range $33.33 - $40.58
Q3 2024
Shares 1,332,411 Value ($000) $53,376 Avg Close $46.53 Range $39.48 - $52.34
Q2 2024
Shares 1,287,111 Value ($000) $61,344 Avg Close $41.01 Range $35.95 - $47.86
Q1 2024
Shares 1,040,111 Value ($000) $45,089 Avg Close $47.67 Range $41.60 - $54.44
Q4 2023
Shares 777,011 Value ($000) $39,309 Avg Close $47.90 Range $41.84 - $52.27
Q3 2023
Shares 604,311 Value ($000) $27,412 Avg Close $41.26 Range $38.26 - $47.72
Q2 2023
Shares 344,211 Value ($000) $14,123 Avg Close $38.43 Range $34.32 - $43.55
Q1 2023
Shares 345,811 Value ($000) $12,359 Avg Close $37.55 Range $32.69 - $41.73
Q4 2022
Shares 634,911 Value ($000) $23,981 Avg Close $42.06 Range $36.69 - $47.74
Q3 2022
Shares 657,511 Value ($000) $29,082 Avg Close $42.14 Range $35.95 - $48.82
Q2 2022
Shares 705,811 Value ($000) $26,129 Avg Close $37.71 Range $31.46 - $44.42
Q1 2022
Shares 611,611 Value ($000) $22,654 Avg Close $32.73 Range $28.25 - $37.15
Q4 2021
Shares 497,411 Value ($000) $15,136 Avg Close $31.48 Range $25.04 - $35.80
Q3 2021
Shares 432,211 Value ($000) $14,496 Avg Close $37.68 Range $33.52 - $40.99
Q2 2021
Shares 525,811 Value ($000) $20,975 Avg Close $39.17 Range $34.43 - $47.87
Q1 2021
Shares 714,411 Value ($000) $32,120 Avg Close $55.77 Range $41.42 - $64.37
Q4 2020
Shares 800,211 Value ($000) $45,244 Avg Close $49.83 Range $45.09 - $60.95
Q3 2020
Shares 1,090,111 Value ($000) $51,726 Avg Close $55.55 Range $47.19 - $63.49
Q2 2020
Shares 1,171,711 Value ($000) $69,084 Avg Close $55.63 Range $45.12 - $61.24
Q1 2020
Shares 1,187,211 Value ($000) $56,131 Avg Close $55.74 Range $39.32 - $64.34
Q4 2019
Shares 1,366,811 Value ($000) $82,569 Avg Close $59.58 Range $53.34 - $66.22
Q3 2019
Shares 1,614,411 Value ($000) $96,719 Avg Close $65.17 Range $58.48 - $73.09
Q2 2019
Shares 1,634,711 Value ($000) $105,063 Avg Close $70.69 Range $61.91 - $86.58
Q1 2019
Shares 806,911 Value ($000) $65,497 Avg Close $64.51 Range $52.45 - $81.59
Q4 2018
Shares 606,911 Value ($000) $32,810 Avg Close $51.00 Range $43.27 - $59.81
Q3 2018
Shares 308,211 Value ($000) $15,898 Avg Close $46.98 Range $41.05 - $54.85
Q2 2018
Shares 47,511 Value ($000) $1,980 Avg Close $44.30 Range $39.07 - $51.00
Q1 2018
Shares 163,511 Value ($000) $7,208 Avg Close $50.80 Range $43.38 - $56.47
Q4 2017
Shares 145,911 Value ($000) $7,339 Avg Close $54.84 Range $50.02 - $65.51
Q3 2017
Shares 35,911 Value ($000) $1,821 Avg Close $52.38 Range $43.75 - $60.01
Q2 2017
Shares 29,111 Value ($000) $1,481 Avg Close $46.57 Range $37.26 - $55.73
Q1 2017
Shares 7,111 Value ($000) $286 Avg Close $44.91 Range $37.29 - $56.91
Q4 2016
Shares 24,811 Value ($000) $1,187 Avg Close $39.57 Range $24.58 - $57.00
Q3 2016
Shares 71,211 Value ($000) $2,609 Avg Close $31.29 Range $23.26 - $40.82
Q2 2016
Shares 165,711 Value ($000) $3,859 Avg Close $32.26 Range $19.59 - $46.75
Q1 2016
Shares 276,411 Value ($000) $11,195 Avg Close $40.62 Range $30.93 - $62.68
Q4 2015
Shares 395,539 Value ($000) $24,496 Avg Close $53.96 Range $38.30 - $65.34