IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Sio Capital Management, LLC's Holding History (CIK: 0001482416)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022

Shares 175,568 Value ($000) $6,503 Avg Close $32.73 Range $28.25 - $37.15

Q4 2021

Shares 322,566 Value ($000) $9,816 Avg Close $31.48 Range $25.04 - $35.80

Q4 2020

Shares 81,026 Value ($000) $4,581 Avg Close $49.83 Range $45.09 - $60.95

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2022	175,568	$6,503	$32.73	$28.25 - $37.15
Q4 2021	322,566	$9,816	$31.48	$25.04 - $35.80
Q4 2020	81,026	$4,581	$49.83	$45.09 - $60.95