IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Hemenway Trust Co LLC's Holding History (CIK: 0001494234)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016

Shares 9,705 Value ($000) $464 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 7,280 Value ($000) $267 Avg Close $31.29 Range $23.26 - $40.82

Q1 2016

Shares 36,240 Value ($000) $1,468 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 36,220 Value ($000) $2,243 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2016	9,705	$464	$39.57	$24.58 - $57.00
Q3 2016	7,280	$267	$31.29	$23.26 - $40.82
Q1 2016	36,240	$1,468	$40.62	$30.93 - $62.68
Q4 2015	36,220	$2,243	$53.96	$38.30 - $65.34