IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Fiera Capital Corp's Holding History (CIK: 0001505817)

Note: Option positions (PUT/CALL) are excluded.

Q3 2018

Shares 492,213 Value ($000) $25,388 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 579,375 Value ($000) $24,143 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 580,852 Value ($000) $25,604 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 608,864 Value ($000) $30,626 Avg Close $54.84 Range $50.02 - $65.51

Q3 2017

Shares 630,312 Value ($000) $31,957 Avg Close $52.38 Range $43.75 - $60.01

Q2 2017

Shares 643,940 Value ($000) $32,757 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 707,212 Value ($000) $28,430 Avg Close $44.91 Range $37.29 - $56.91

Q4 2016

Shares 772,059 Value ($000) $36,928 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 931,874 Value ($000) $34,144 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 958,620 Value ($000) $22,326 Avg Close $32.26 Range $19.59 - $46.75

Q4 2015

Shares 4,900 Value ($000) $303 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2018	492,213	$25,388	$46.98	$41.05 - $54.85
Q2 2018	579,375	$24,143	$44.30	$39.07 - $51.00
Q1 2018	580,852	$25,604	$50.80	$43.38 - $56.47
Q4 2017	608,864	$30,626	$54.84	$50.02 - $65.51
Q3 2017	630,312	$31,957	$52.38	$43.75 - $60.01
Q2 2017	643,940	$32,757	$46.57	$37.26 - $55.73
Q1 2017	707,212	$28,430	$44.91	$37.29 - $56.91
Q4 2016	772,059	$36,928	$39.57	$24.58 - $57.00
Q3 2016	931,874	$34,144	$31.29	$23.26 - $40.82
Q2 2016	958,620	$22,326	$32.26	$19.59 - $46.75
Q4 2015	4,900	$303	$53.96	$38.30 - $65.34