IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

TOBAM's Holding History (CIK: 0001527488)

Note: Option positions (PUT/CALL) are excluded.

Q4 2020

Shares 598 Value ($000) $34 Avg Close $49.83 Range $45.09 - $60.95

Q3 2020

Shares 598 Value ($000) $28 Avg Close $55.55 Range $47.19 - $63.49

Q2 2016

Shares 198,811 Value ($000) $4,630 Avg Close $32.26 Range $19.59 - $46.75

Q4 2015

Shares 171,344 Value ($000) $10,611 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2020	598	$34	$49.83	$45.09 - $60.95
Q3 2020	598	$28	$55.55	$47.19 - $63.49
Q2 2016	198,811	$4,630	$32.26	$19.59 - $46.75
Q4 2015	171,344	$10,611	$53.96	$38.30 - $65.34