IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Edgestream Partners, L.P.'s Holding History (CIK: 0001535061)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 5,450 Value ($000) $357 Avg Close $48.82 Range $39.72 - $65.55

Q1 2024

Shares 17,646 Value ($000) $765 Avg Close $47.67 Range $41.60 - $54.44

Q4 2022

Shares 27,393 Value ($000) $1,035 Avg Close $42.06 Range $36.69 - $47.74

Q2 2021

Shares 31,262 Value ($000) $1,247 Avg Close $39.17 Range $34.43 - $47.87

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	5,450	$357	$48.82	$39.72 - $65.55
Q1 2024	17,646	$765	$47.67	$41.60 - $54.44
Q4 2022	27,393	$1,035	$42.06	$36.69 - $47.74
Q2 2021	31,262	$1,247	$39.17	$34.43 - $47.87