IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Crestline Management, LP's Holding History (CIK: 0001536054)

Note: Option positions (PUT/CALL) are excluded.

Q2 2018

Shares 21,450 Value ($000) $894 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 25,553 Value ($000) $1,126 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 25,526 Value ($000) $1,284 Avg Close $54.84 Range $50.02 - $65.51

Q3 2017

Shares 50,957 Value ($000) $2,584 Avg Close $52.38 Range $43.75 - $60.01

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2018	21,450	$894	$44.30	$39.07 - $51.00
Q1 2018	25,553	$1,126	$50.80	$43.38 - $56.47
Q4 2017	25,526	$1,284	$54.84	$50.02 - $65.51
Q3 2017	50,957	$2,584	$52.38	$43.75 - $60.01