IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Spark Investment Management LLC's Holding History (CIK: 0001554871)

Note: Option positions (PUT/CALL) are excluded.

Q3 2018

Shares 17,900 Value ($000) $923 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 150,600 Value ($000) $6,275 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 42,600 Value ($000) $1,877 Avg Close $50.80 Range $43.38 - $56.47

Q1 2017

Shares 19,300 Value ($000) $775 Avg Close $44.91 Range $37.29 - $56.91

Q2 2016

Shares 79,400 Value ($000) $1,849 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 67,200 Value ($000) $2,721 Avg Close $40.62 Range $30.93 - $62.68

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2018	17,900	$923	$46.98	$41.05 - $54.85
Q2 2018	150,600	$6,275	$44.30	$39.07 - $51.00
Q1 2018	42,600	$1,877	$50.80	$43.38 - $56.47
Q1 2017	19,300	$775	$44.91	$37.29 - $56.91
Q2 2016	79,400	$1,849	$32.26	$19.59 - $46.75
Q1 2016	67,200	$2,721	$40.62	$30.93 - $62.68