IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

LMR Partners LLP's Holding History (CIK: 0001578621)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 15,000 Value ($000) $1,187 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 37,600 Value ($000) $2,460 Avg Close $48.82 Range $39.72 - $65.55

Q4 2019

Shares 28,809 Value ($000) $1,740 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 4,028 Value ($000) $241 Avg Close $65.17 Range $58.48 - $73.09

Q1 2019

Shares 51,950 Value ($000) $4,217 Avg Close $64.51 Range $52.45 - $81.59

Q3 2016

Shares 144,790 Value ($000) $5,305 Avg Close $31.29 Range $23.26 - $40.82

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	15,000	$1,187	$75.30	$64.93 - $83.61
Q3 2025	37,600	$2,460	$48.82	$39.72 - $65.55
Q4 2019	28,809	$1,740	$59.58	$53.34 - $66.22
Q3 2019	4,028	$241	$65.17	$58.48 - $73.09
Q1 2019	51,950	$4,217	$64.51	$52.45 - $81.59
Q3 2016	144,790	$5,305	$31.29	$23.26 - $40.82