IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Swiss National Bank's Holding History (CIK: 0001582202)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 298,500 Value ($000) $23,614 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 293,100 Value ($000) $19,175 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 288,600 Value ($000) $11,403 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 275,300 Value ($000) $8,306 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 279,200 Value ($000) $9,761 Avg Close $37.38 Range $33.33 - $40.58

Q3 2024

Shares 256,600 Value ($000) $10,279 Avg Close $46.53 Range $39.48 - $52.34

Q2 2024

Shares 258,000 Value ($000) $12,296 Avg Close $41.01 Range $35.95 - $47.86

Q1 2024

Shares 254,900 Value ($000) $11,050 Avg Close $47.67 Range $41.60 - $54.44

Q4 2023

Shares 254,300 Value ($000) $12,865 Avg Close $47.90 Range $41.84 - $52.27

Q3 2023

Shares 283,100 Value ($000) $12,841 Avg Close $41.26 Range $38.26 - $47.72

Q2 2023

Shares 280,100 Value ($000) $11,493 Avg Close $38.43 Range $34.32 - $43.55

Q1 2023

Shares 275,900 Value ($000) $9,861 Avg Close $37.55 Range $32.69 - $41.73

Q4 2022

Shares 308,400 Value ($000) $11,648 Avg Close $42.06 Range $36.69 - $47.74

Q3 2022

Shares 302,600 Value ($000) $13,384 Avg Close $42.14 Range $35.95 - $48.82

Q2 2022

Shares 299,300 Value ($000) $11,080 Avg Close $37.71 Range $31.46 - $44.42

Q1 2022

Shares 300,500 Value ($000) $11,131 Avg Close $32.73 Range $28.25 - $37.15

Q4 2021

Shares 279,300 Value ($000) $8,499 Avg Close $31.48 Range $25.04 - $35.80

Q3 2021

Shares 279,900 Value ($000) $9,388 Avg Close $37.68 Range $33.52 - $40.99

Q2 2021

Shares 279,900 Value ($000) $11,165 Avg Close $39.17 Range $34.43 - $47.87

Q1 2021

Shares 510,359 Value ($000) $22,946 Avg Close $55.77 Range $41.42 - $64.37

Q4 2020

Shares 501,659 Value ($000) $28,364 Avg Close $49.83 Range $45.09 - $60.95

Q3 2020

Shares 515,459 Value ($000) $24,459 Avg Close $55.55 Range $47.19 - $63.49

Q2 2020

Shares 528,459 Value ($000) $31,158 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 518,759 Value ($000) $24,527 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 420,859 Value ($000) $25,424 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 440,159 Value ($000) $26,370 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 428,700 Value ($000) $27,553 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 238,100 Value ($000) $19,327 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 230,600 Value ($000) $12,466 Avg Close $51.00 Range $43.27 - $59.81

Q3 2018

Shares 218,900 Value ($000) $11,291 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 216,700 Value ($000) $9,030 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 216,700 Value ($000) $9,552 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 211,800 Value ($000) $10,654 Avg Close $54.84 Range $50.02 - $65.51

Q3 2017

Shares 207,300 Value ($000) $10,510 Avg Close $52.38 Range $43.75 - $60.01

Q2 2017

Shares 201,900 Value ($000) $10,271 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 200,200 Value ($000) $8,048 Avg Close $44.91 Range $37.29 - $56.91

Q4 2016

Shares 198,800 Value ($000) $9,509 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 236,200 Value ($000) $8,654 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 338,200 Value ($000) $7,877 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 312,100 Value ($000) $12,114 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 217,000 Value ($000) $13,439 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	298,500	$23,614	$75.30	$64.93 - $83.61
Q3 2025	293,100	$19,175	$48.82	$39.72 - $65.55
Q2 2025	288,600	$11,403	$32.73	$23.95 - $40.61
Q1 2025	275,300	$8,306	$32.75	$29.61 - $35.48
Q4 2024	279,200	$9,761	$37.38	$33.33 - $40.58
Q3 2024	256,600	$10,279	$46.53	$39.48 - $52.34
Q2 2024	258,000	$12,296	$41.01	$35.95 - $47.86
Q1 2024	254,900	$11,050	$47.67	$41.60 - $54.44
Q4 2023	254,300	$12,865	$47.90	$41.84 - $52.27
Q3 2023	283,100	$12,841	$41.26	$38.26 - $47.72
Q2 2023	280,100	$11,493	$38.43	$34.32 - $43.55
Q1 2023	275,900	$9,861	$37.55	$32.69 - $41.73
Q4 2022	308,400	$11,648	$42.06	$36.69 - $47.74
Q3 2022	302,600	$13,384	$42.14	$35.95 - $48.82
Q2 2022	299,300	$11,080	$37.71	$31.46 - $44.42
Q1 2022	300,500	$11,131	$32.73	$28.25 - $37.15
Q4 2021	279,300	$8,499	$31.48	$25.04 - $35.80
Q3 2021	279,900	$9,388	$37.68	$33.52 - $40.99
Q2 2021	279,900	$11,165	$39.17	$34.43 - $47.87
Q1 2021	510,359	$22,946	$55.77	$41.42 - $64.37
Q4 2020	501,659	$28,364	$49.83	$45.09 - $60.95
Q3 2020	515,459	$24,459	$55.55	$47.19 - $63.49
Q2 2020	528,459	$31,158	$55.63	$45.12 - $61.24
Q1 2020	518,759	$24,527	$55.74	$39.32 - $64.34
Q4 2019	420,859	$25,424	$59.58	$53.34 - $66.22
Q3 2019	440,159	$26,370	$65.17	$58.48 - $73.09
Q2 2019	428,700	$27,553	$70.69	$61.91 - $86.58
Q1 2019	238,100	$19,327	$64.51	$52.45 - $81.59
Q4 2018	230,600	$12,466	$51.00	$43.27 - $59.81
Q3 2018	218,900	$11,291	$46.98	$41.05 - $54.85
Q2 2018	216,700	$9,030	$44.30	$39.07 - $51.00
Q1 2018	216,700	$9,552	$50.80	$43.38 - $56.47
Q4 2017	211,800	$10,654	$54.84	$50.02 - $65.51
Q3 2017	207,300	$10,510	$52.38	$43.75 - $60.01
Q2 2017	201,900	$10,271	$46.57	$37.26 - $55.73
Q1 2017	200,200	$8,048	$44.91	$37.29 - $56.91
Q4 2016	198,800	$9,509	$39.57	$24.58 - $57.00
Q3 2016	236,200	$8,654	$31.29	$23.26 - $40.82
Q2 2016	338,200	$7,877	$32.26	$19.59 - $46.75
Q1 2016	312,100	$12,114	$40.62	$30.93 - $62.68
Q4 2015	217,000	$13,439	$53.96	$38.30 - $65.34