IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

New England Research & Management, Inc.'s Holding History (CIK: 0001596077)

Note: Option positions (PUT/CALL) are excluded.

Q2 2020

Shares 18,890 Value ($000) $1,114 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 20,040 Value ($000) $947 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 9,550 Value ($000) $577 Avg Close $59.58 Range $53.34 - $66.22

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2020	18,890	$1,114	$55.63	$45.12 - $61.24
Q1 2020	20,040	$947	$55.74	$39.32 - $64.34
Q4 2019	9,550	$577	$59.58	$53.34 - $66.22