IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Tradewinds Capital Management, LLC's Holding History (CIK: 0001616026)

Note: Option positions (PUT/CALL) are excluded.

Q2 2018

Shares 12 Value ($000) $1 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 12 Value ($000) $1 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 12 Value ($000) $1 Avg Close $54.84 Range $50.02 - $65.51

Q1 2016

Shares 170 Value ($000) $7 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 170 Value ($000) $11 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2018	12	$1	$44.30	$39.07 - $51.00
Q1 2018	12	$1	$50.80	$43.38 - $56.47
Q4 2017	12	$1	$54.84	$50.02 - $65.51
Q1 2016	170	$7	$40.62	$30.93 - $62.68
Q4 2015	170	$11	$53.96	$38.30 - $65.34