IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Trexquant Investment LP's Holding History (CIK: 0001633445)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 132,241 Value ($000) $10,462 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 215,121 Value ($000) $14,073 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 128,869 Value ($000) $5,092 Avg Close $32.73 Range $23.95 - $40.61

Q4 2024

Shares 84,913 Value ($000) $2,969 Avg Close $37.38 Range $33.33 - $40.58

Q3 2024

Shares 130,858 Value ($000) $5,242 Avg Close $46.53 Range $39.48 - $52.34

Q2 2024

Shares 30,086 Value ($000) $1,434 Avg Close $41.01 Range $35.95 - $47.86

Q1 2024

Shares 85,352 Value ($000) $3,700 Avg Close $47.67 Range $41.60 - $54.44

Q4 2023

Shares 112,987 Value ($000) $5,716 Avg Close $47.90 Range $41.84 - $52.27

Q3 2023

Shares 183,349 Value ($000) $8,317 Avg Close $41.26 Range $38.26 - $47.72

Q2 2023

Shares 104,625 Value ($000) $4,293 Avg Close $38.43 Range $34.32 - $43.55

Q1 2023

Shares 32,612 Value ($000) $1,166 Avg Close $37.55 Range $32.69 - $41.73

Q4 2022

Shares 46,945 Value ($000) $1,773 Avg Close $42.06 Range $36.69 - $47.74

Q3 2022

Shares 55,564 Value ($000) $2,458 Avg Close $42.14 Range $35.95 - $48.82

Q2 2022

Shares 28,423 Value ($000) $1,052 Avg Close $37.71 Range $31.46 - $44.42

Q1 2022

Shares 47,762 Value ($000) $1,769 Avg Close $32.73 Range $28.25 - $37.15

Q4 2021

Shares 33,903 Value ($000) $1,032 Avg Close $31.48 Range $25.04 - $35.80

Q3 2021

Shares 13,297 Value ($000) $446 Avg Close $37.68 Range $33.52 - $40.99

Q2 2020

Shares 29,759 Value ($000) $1,755 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 47,499 Value ($000) $2,246 Avg Close $55.74 Range $39.32 - $64.34

Q2 2019

Shares 11,383 Value ($000) $732 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 30,681 Value ($000) $2,490 Avg Close $64.51 Range $52.45 - $81.59

Q2 2017

Shares 4,580 Value ($000) $233 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 6,900 Value ($000) $277 Avg Close $44.91 Range $37.29 - $56.91

Q4 2015

Shares 13,500 Value ($000) $836 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	132,241	$10,462	$75.30	$64.93 - $83.61
Q3 2025	215,121	$14,073	$48.82	$39.72 - $65.55
Q2 2025	128,869	$5,092	$32.73	$23.95 - $40.61
Q4 2024	84,913	$2,969	$37.38	$33.33 - $40.58
Q3 2024	130,858	$5,242	$46.53	$39.48 - $52.34
Q2 2024	30,086	$1,434	$41.01	$35.95 - $47.86
Q1 2024	85,352	$3,700	$47.67	$41.60 - $54.44
Q4 2023	112,987	$5,716	$47.90	$41.84 - $52.27
Q3 2023	183,349	$8,317	$41.26	$38.26 - $47.72
Q2 2023	104,625	$4,293	$38.43	$34.32 - $43.55
Q1 2023	32,612	$1,166	$37.55	$32.69 - $41.73
Q4 2022	46,945	$1,773	$42.06	$36.69 - $47.74
Q3 2022	55,564	$2,458	$42.14	$35.95 - $48.82
Q2 2022	28,423	$1,052	$37.71	$31.46 - $44.42
Q1 2022	47,762	$1,769	$32.73	$28.25 - $37.15
Q4 2021	33,903	$1,032	$31.48	$25.04 - $35.80
Q3 2021	13,297	$446	$37.68	$33.52 - $40.99
Q2 2020	29,759	$1,755	$55.63	$45.12 - $61.24
Q1 2020	47,499	$2,246	$55.74	$39.32 - $64.34
Q2 2019	11,383	$732	$70.69	$61.91 - $86.58
Q1 2019	30,681	$2,490	$64.51	$52.45 - $81.59
Q2 2017	4,580	$233	$46.57	$37.26 - $55.73
Q1 2017	6,900	$277	$44.91	$37.29 - $56.91
Q4 2015	13,500	$836	$53.96	$38.30 - $65.34