IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Man Group plc's Holding History (CIK: 0001637460)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 166,042 Value ($000) $13,136 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 333,820 Value ($000) $21,839 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 8,969 Value ($000) $354 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 10,033 Value ($000) $303 Avg Close $32.75 Range $29.61 - $35.48

Q4 2024

Shares 8,315 Value ($000) $291 Avg Close $37.38 Range $33.33 - $40.58

Q3 2024

Shares 596,263 Value ($000) $23,886 Avg Close $46.53 Range $39.48 - $52.34

Q2 2024

Shares 633,409 Value ($000) $30,188 Avg Close $41.01 Range $35.95 - $47.86

Q1 2024

Shares 253,221 Value ($000) $10,977 Avg Close $47.67 Range $41.60 - $54.44

Q4 2023

Shares 78,475 Value ($000) $3,970 Avg Close $47.90 Range $41.84 - $52.27

Q3 2023

Shares 163,947 Value ($000) $7,437 Avg Close $41.26 Range $38.26 - $47.72

Q1 2023

Shares 250,301 Value ($000) $8,946 Avg Close $37.55 Range $32.69 - $41.73

Q4 2022

Shares 230,525 Value ($000) $8,707 Avg Close $42.06 Range $36.69 - $47.74

Q3 2022

Shares 177,597 Value ($000) $7,855 Avg Close $42.14 Range $35.95 - $48.82

Q2 2022

Shares 11,930 Value ($000) $442 Avg Close $37.71 Range $31.46 - $44.42

Q3 2020

Shares 6,204 Value ($000) $294 Avg Close $55.55 Range $47.19 - $63.49

Q2 2020

Shares 116,012 Value ($000) $6,840 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 9,700 Value ($000) $459 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 58,670 Value ($000) $3,544 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 54,248 Value ($000) $3,250 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 82,955 Value ($000) $5,331 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 20,924 Value ($000) $1,698 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 5,124 Value ($000) $277 Avg Close $51.00 Range $43.27 - $59.81

Q3 2018

Shares 12,077 Value ($000) $623 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 18,109 Value ($000) $755 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 4,600 Value ($000) $203 Avg Close $50.80 Range $43.38 - $56.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	166,042	$13,136	$75.30	$64.93 - $83.61
Q3 2025	333,820	$21,839	$48.82	$39.72 - $65.55
Q2 2025	8,969	$354	$32.73	$23.95 - $40.61
Q1 2025	10,033	$303	$32.75	$29.61 - $35.48
Q4 2024	8,315	$291	$37.38	$33.33 - $40.58
Q3 2024	596,263	$23,886	$46.53	$39.48 - $52.34
Q2 2024	633,409	$30,188	$41.01	$35.95 - $47.86
Q1 2024	253,221	$10,977	$47.67	$41.60 - $54.44
Q4 2023	78,475	$3,970	$47.90	$41.84 - $52.27
Q3 2023	163,947	$7,437	$41.26	$38.26 - $47.72
Q1 2023	250,301	$8,946	$37.55	$32.69 - $41.73
Q4 2022	230,525	$8,707	$42.06	$36.69 - $47.74
Q3 2022	177,597	$7,855	$42.14	$35.95 - $48.82
Q2 2022	11,930	$442	$37.71	$31.46 - $44.42
Q3 2020	6,204	$294	$55.55	$47.19 - $63.49
Q2 2020	116,012	$6,840	$55.63	$45.12 - $61.24
Q1 2020	9,700	$459	$55.74	$39.32 - $64.34
Q4 2019	58,670	$3,544	$59.58	$53.34 - $66.22
Q3 2019	54,248	$3,250	$65.17	$58.48 - $73.09
Q2 2019	82,955	$5,331	$70.69	$61.91 - $86.58
Q1 2019	20,924	$1,698	$64.51	$52.45 - $81.59
Q4 2018	5,124	$277	$51.00	$43.27 - $59.81
Q3 2018	12,077	$623	$46.98	$41.05 - $54.85
Q2 2018	18,109	$755	$44.30	$39.07 - $51.00
Q1 2018	4,600	$203	$50.80	$43.38 - $56.47