IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

EDMOND DE ROTHSCHILD HOLDING S.A.'s Holding History (CIK: 0001649647)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 122,190 Value ($000) $9,666 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 156,690 Value ($000) $10,251 Avg Close $48.82 Range $39.72 - $65.55

Q2 2025

Shares 197,600 Value ($000) $7,807 Avg Close $32.73 Range $23.95 - $40.61

Q1 2025

Shares 124,200 Value ($000) $3,747 Avg Close $32.75 Range $29.61 - $35.48

Q1 2021

Shares 86,250 Value ($000) $3,878 Avg Close $55.77 Range $41.42 - $64.37

Q4 2020

Shares 113,750 Value ($000) $6,431 Avg Close $49.83 Range $45.09 - $60.95

Q3 2020

Shares 113,750 Value ($000) $5,397 Avg Close $55.55 Range $47.19 - $63.49

Q2 2020

Shares 113,750 Value ($000) $6,707 Avg Close $55.63 Range $45.12 - $61.24

Q1 2020

Shares 113,750 Value ($000) $5,378 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 113,848 Value ($000) $6,878 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 106,120 Value ($000) $6,358 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 107,487 Value ($000) $6,908 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 138,702 Value ($000) $11,258 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 142,517 Value ($000) $7,705 Avg Close $51.00 Range $43.27 - $59.81

Q3 2018

Shares 140,383 Value ($000) $7,241 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 176,198 Value ($000) $7,342 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 192,198 Value ($000) $8,472 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 240,098 Value ($000) $12,077 Avg Close $54.84 Range $50.02 - $65.51

Q3 2017

Shares 240,503 Value ($000) $12,194 Avg Close $52.38 Range $43.75 - $60.01

Q2 2017

Shares 240,503 Value ($000) $12,235 Avg Close $46.57 Range $37.26 - $55.73

Q1 2017

Shares 240,503 Value ($000) $9,668 Avg Close $44.91 Range $37.29 - $56.91

Q4 2016

Shares 200,503 Value ($000) $9,590 Avg Close $39.57 Range $24.58 - $57.00

Q3 2016

Shares 180,405 Value ($000) $6,610 Avg Close $31.29 Range $23.26 - $40.82

Q2 2016

Shares 200,000 Value ($000) $4,658 Avg Close $32.26 Range $19.59 - $46.75

Q1 2016

Shares 200,000 Value ($000) $8,100 Avg Close $40.62 Range $30.93 - $62.68

Q4 2015

Shares 200,000 Value ($000) $12,386 Avg Close $53.96 Range $38.30 - $65.34

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	122,190	$9,666	$75.30	$64.93 - $83.61
Q3 2025	156,690	$10,251	$48.82	$39.72 - $65.55
Q2 2025	197,600	$7,807	$32.73	$23.95 - $40.61
Q1 2025	124,200	$3,747	$32.75	$29.61 - $35.48
Q1 2021	86,250	$3,878	$55.77	$41.42 - $64.37
Q4 2020	113,750	$6,431	$49.83	$45.09 - $60.95
Q3 2020	113,750	$5,397	$55.55	$47.19 - $63.49
Q2 2020	113,750	$6,707	$55.63	$45.12 - $61.24
Q1 2020	113,750	$5,378	$55.74	$39.32 - $64.34
Q4 2019	113,848	$6,878	$59.58	$53.34 - $66.22
Q3 2019	106,120	$6,358	$65.17	$58.48 - $73.09
Q2 2019	107,487	$6,908	$70.69	$61.91 - $86.58
Q1 2019	138,702	$11,258	$64.51	$52.45 - $81.59
Q4 2018	142,517	$7,705	$51.00	$43.27 - $59.81
Q3 2018	140,383	$7,241	$46.98	$41.05 - $54.85
Q2 2018	176,198	$7,342	$44.30	$39.07 - $51.00
Q1 2018	192,198	$8,472	$50.80	$43.38 - $56.47
Q4 2017	240,098	$12,077	$54.84	$50.02 - $65.51
Q3 2017	240,503	$12,194	$52.38	$43.75 - $60.01
Q2 2017	240,503	$12,235	$46.57	$37.26 - $55.73
Q1 2017	240,503	$9,668	$44.91	$37.29 - $56.91
Q4 2016	200,503	$9,590	$39.57	$24.58 - $57.00
Q3 2016	180,405	$6,610	$31.29	$23.26 - $40.82
Q2 2016	200,000	$4,658	$32.26	$19.59 - $46.75
Q1 2016	200,000	$8,100	$40.62	$30.93 - $62.68
Q4 2015	200,000	$12,386	$53.96	$38.30 - $65.34