IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

NVWM, LLC's Holding History (CIK: 0001697274)

Note: Option positions (PUT/CALL) are excluded.

Q2 2019

Shares 200 Value ($000) $13 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 200 Value ($000) $16 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 200 Value ($000) $11 Avg Close $51.00 Range $43.27 - $59.81

Q3 2018

Shares 200 Value ($000) $10 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 200 Value ($000) $8 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 200 Value ($000) $8 Avg Close $50.80 Range $43.38 - $56.47

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2019	200	$13	$70.69	$61.91 - $86.58
Q1 2019	200	$16	$64.51	$52.45 - $81.59
Q4 2018	200	$11	$51.00	$43.27 - $59.81
Q3 2018	200	$10	$46.98	$41.05 - $54.85
Q2 2018	200	$8	$44.30	$39.07 - $51.00
Q1 2018	200	$8	$50.80	$43.38 - $56.47