IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

AE Wealth Management LLC's Holding History (CIK: 0001697723)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 4,403 Value ($000) $348 Avg Close $75.30 Range $64.93 - $83.61

Q4 2021

Shares 26,085 Value ($000) $794 Avg Close $31.48 Range $25.04 - $35.80

Q3 2019

Shares 6,119 Value ($000) $367 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 6,039 Value ($000) $388 Avg Close $70.69 Range $61.91 - $86.58

Q1 2019

Shares 5,930 Value ($000) $481 Avg Close $64.51 Range $52.45 - $81.59

Q4 2018

Shares 5,790 Value ($000) $313 Avg Close $51.00 Range $43.27 - $59.81

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	4,403	$348	$75.30	$64.93 - $83.61
Q4 2021	26,085	$794	$31.48	$25.04 - $35.80
Q3 2019	6,119	$367	$65.17	$58.48 - $73.09
Q2 2019	6,039	$388	$70.69	$61.91 - $86.58
Q1 2019	5,930	$481	$64.51	$52.45 - $81.59
Q4 2018	5,790	$313	$51.00	$43.27 - $59.81