IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Achmea Investment Management B.V.'s Holding History (CIK: 0001697765)

Note: Option positions (PUT/CALL) are excluded.

Q4 2019

Shares 6,928 Value ($000) $419 Avg Close $59.58 Range $53.34 - $66.22

Q3 2019

Shares 6,928 Value ($000) $415 Avg Close $65.17 Range $58.48 - $73.09

Q2 2019

Shares 6,928 Value ($000) $445 Avg Close $70.69 Range $61.91 - $86.58

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2019	6,928	$419	$59.58	$53.34 - $66.22
Q3 2019	6,928	$415	$65.17	$58.48 - $73.09
Q2 2019	6,928	$445	$70.69	$61.91 - $86.58