IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Summit Trail Advisors, LLC's Holding History (CIK: 0001698478)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 9,943 Value ($000) $787 Avg Close $75.30 Range $64.93 - $83.61

Q3 2025

Shares 6,205 Value ($000) $406 Avg Close $48.82 Range $39.72 - $65.55

Q1 2018

Shares 20,574 Value ($000) $523 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 17,093 Value ($000) $898 Avg Close $54.84 Range $50.02 - $65.51

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	9,943	$787	$75.30	$64.93 - $83.61
Q3 2025	6,205	$406	$48.82	$39.72 - $65.55
Q1 2018	20,574	$523	$50.80	$43.38 - $56.47
Q4 2017	17,093	$898	$54.84	$50.02 - $65.51