IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Qube Research & Technologies Ltd's Holding History (CIK: 0001729829)

Note: Option positions (PUT/CALL) are excluded.

Q4 2022

Shares 330,724 Value ($000) $12,491 Avg Close $42.06 Range $36.69 - $47.74

Q3 2022

Shares 11,697 Value ($000) $517 Avg Close $42.14 Range $35.95 - $48.82

Q3 2020

Shares 131,618 Value ($000) $6,245 Avg Close $55.55 Range $47.19 - $63.49

Q1 2020

Shares 11,225 Value ($000) $531 Avg Close $55.74 Range $39.32 - $64.34

Q4 2019

Shares 5,717 Value ($000) $345 Avg Close $59.58 Range $53.34 - $66.22

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2022	330,724	$12,491	$42.06	$36.69 - $47.74
Q3 2022	11,697	$517	$42.14	$35.95 - $48.82
Q3 2020	131,618	$6,245	$55.55	$47.19 - $63.49
Q1 2020	11,225	$531	$55.74	$39.32 - $64.34
Q4 2019	5,717	$345	$59.58	$53.34 - $66.22