IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Signature Wealth Management Group's Holding History (CIK: 0001736666)

Note: Option positions (PUT/CALL) are excluded.

Q3 2018

Shares 250 Value ($000) $12 Avg Close $46.98 Range $41.05 - $54.85

Q2 2018

Shares 250 Value ($000) $10 Avg Close $44.30 Range $39.07 - $51.00

Q1 2018

Shares 250 Value ($000) $11 Avg Close $50.80 Range $43.38 - $56.47

Q4 2017

Shares 250 Value ($000) $13 Avg Close $54.84 Range $50.02 - $65.51

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2018	250	$12	$46.98	$41.05 - $54.85
Q2 2018	250	$10	$44.30	$39.07 - $51.00
Q1 2018	250	$11	$50.80	$43.38 - $56.47
Q4 2017	250	$13	$54.84	$50.02 - $65.51